Hypercycle: A Principle of Natural Self-Organization
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110 filesLesson 1
- HTML00_Lesson 1 Eigen, Schuster, Hypercycle.html
- HTML01_Natural Self-Organization and the Hypercycle.html
- HTML02_Species Diversity and Molecular Uniformity.html
- HTML03_Three Central Theses of Hypercycle Theory.html
- HTML04_Self-Reproduction, Mutation, and Copying Fidelity.html
- HTML05_The Error Threshold for a Single Replicative Unit.html
- HTML06_Catalytic Cycles, Autocatalysis, and Templates.html
- HTML07_Enzyme Turnover, RNA Replication, and DNA Replication.html
- HTML08_Why a Single Short Replicative Unit Cannot Start Translation.html
- HTML09_Integration Without Ligation Functional Coupling.html
- HTML10_From Molecular Integration to Hypercyclic Organization.html
- MDHYC-1979-Lesson-1_lecture_notes.md
Lesson 2
- HTML00_Lesson 2 Catalytic, Which, System.html
- HTML01_Catalytic Hypercycles and Molecular Selection.html
- HTML02_Catalytic, Autocatalytic, and Hypercyclic Growth.html
- HTML03_Necessary Prerequisites of Darwinian Systems.html
- HTML04_Selection Equations Under Constant Organization.html
- HTML05_Selective Value and Average Excess Productivity.html
- HTML06_Mutation-Selection Balance and the Quasi-Species.html
- HTML07_The Error Threshold and Limits of Information.html
- HTML08_Why Hypercyclic Organization of Mutant Genes.html
- HTML09_Hypercycle Stability and Parasitic Challenge.html
- HTML10_Catalytic Hypercycles in the Darwinian Framework.html
- MDHYC-1979-Lesson-2_lecture_notes.md
Lesson 3
- HTML00_Lesson 3 Error Threshold and Early Replicative Units.html
- HTML01_Why the Error Threshold Governs Stable Information.html
- HTML02_The Sentence-Evolution Game and the Error Threshold.html
- HTML03_Applying q̄m, σm, and vm to Predict Information Loss.html
- HTML04_Qβ Phage Mutagenesis Wild-Type and Mutant Distributions.html
- HTML05_RNA Fidelity, DNA Proofreading, and Recombination.html
- HTML06_Early Replicative Units tRNA-Like Molecules and Functional Linkage.html
- HTML07_The Need for Hypercyclic Organization.html
- HTML08_Limits of Hypercyclic Organization and Parasite Dynamics.html
- HTML09_First Enzymes and Functionally Active Proteins.html
- HTML10_Synthesis Error Threshold, Early Replicators, and Hypercycle Limits.html
- MDHYC-1979-Lesson-3_lecture_notes.md
Lesson 4
- HTML00_Lesson 4 Advantage, Word, Words.html
- HTML01_Selectively Equivalent Words in the Sentence Game.html
- HTML02_From Linear Coupling to Cyclic Coupling.html
- HTML03_Rate Equations Amplification, Decomposition, and Flux.html
- HTML04_Growth Degrees and Selection Behavior.html
- HTML05_Check Growth Degree Classification.html
- HTML06_Fixed-Point Analysis in the Concentration Simplex.html
- HTML07_Normal-Mode Linearization and the Jacobian.html
- HTML08_Applying Fixed-Point Analysis to Quasi-Species.html
- HTML09_Hypercycle Integration Advantages and Limits.html
- HTML10_Synthesis from Words to Hypercycles.html
- MDHYC-1979-Lesson-4_lecture_notes.md
Lesson 5
- HTML00_Lesson 5 Selection, Species, Will.html
- HTML01_The Integration Problem in Molecular Selection.html
- HTML02_Fixed Points of Open Catalytic Chains.html
- HTML03_Stability Conditions and the Failure of Joint Function.html
- HTML04_Branched Catalytic Networks and Once-for-Ever Selection.html
- HTML05_Ring Closure and Hypercyclic Growth Functions.html
- HTML06_Exponent Matrix and Hypercycle Classification.html
- HTML07_Central and Corner Fixed Points of the Hypercycle.html
- HTML08_Normal Modes and Dimensional Character.html
- HTML09_Lyapunov Stability and Broken Hypercycles.html
- HTML10_Limit Cycles and Coherent Growth.html
- MDHYC-1979-Lesson-5_lecture_notes.md
Lesson 6
- HTML00_Lesson 6 Concentration, Hypercycles, Fixed.html
- HTML01_From Stationary States to Long-Term Hypercycle Dynamics.html
- HTML02_Limit Cycles for Hypercycles of Dimension Five and Higher.html
- HTML03_Concentration Pulses from Unequal Rate Constants.html
- HTML04_Hypercycles with Translation Coupled Replication and Polypeptide Synthesis.html
- HTML05_Complex Formation and Association Constants.html
- HTML06_Low-Concentration Limit of Translation-Coupled Hypercycles.html
- HTML07_High-Concentration Limit and Saturating Kinetics.html
- HTML08_Hopf Bifurcation and Critical Slowing Down.html
- HTML09_Internal Equilibration and Competition Between Hypercycles.html
- HTML10_Parasitic Coupling, Integration, and Limits of Hypercyclic Organization.html
- MDHYC-1979-Lesson-6_lecture_notes.md
Lesson 7
- HTML00_Lesson 7 Translation, Which, Acids.html
- HTML01_From Hypercycle Dynamics to Primordial Translation.html
- HTML02_Minimum Replicase and Synthetase Scheme.html
- HTML03_Catalytic Closure and Internal Competition.html
- HTML04_Primordial Coding and Comma-Free Frames.html
- HTML05_Rry and Rny Code Patterns.html
- HTML06_Ribosome-Free Peptide Transfer.html
- HTML07_Gc-Rich Replication and Fidelity.html
- HTML08_First Codons Ggc and Gcc.html
- HTML09_Extending the Code to the Primary Alphabet.html
- HTML10_Synthesis of Translation and Primordial Coding.html
- MDHYC-1979-Lesson-7_lecture_notes.md
Lesson 8
- HTML00_Lesson 8 Acid, Amino, Acids.html
- HTML01_Prebiotic Amino Acids and the First Translation Apparatus.html
- HTML02_Aliphatic Amino Acids in the Primordial Environment.html
- HTML03_Abundance Order and First Gc-Frame Codon Assignments.html
- HTML04_The Nucleation Problem of Hypercycles.html
- HTML05_Emergence from a Gc-Rich Quasi-Species.html
- HTML06_Fixed-Point Analysis of a Two-Membered Hypercycle.html
- HTML07_Coupling Regimes in the Two-Membered Hypercycle.html
- HTML08_Generalizing the Evolution Criterion to N-Membered Cycles.html
- HTML09_Evidence for Dual-Purpose RNA Adapters and Messengers.html
- HTML10_From Functional Coupling to the First Enzymes.html
- MDHYC-1979-Lesson-8_lecture_notes.md
Lesson 9
- HTML00_Lesson 9 Have, Translation, Will.html
- HTML01_Limits of Functional Coupling.html
- HTML02_Mutant Load and the Case for Hypercyclic Organization.html
- HTML03_Routes to Integration.html
- HTML04_Starting Translation and Comma-Free Messengers.html
- HTML05_Heterogeneous Interface Model.html
- HTML06_Realistic Boundary Conditions Temperature and Fidelity.html
- HTML07_From Macromolecules to Codon Assignments.html
- HTML08_Compartmentalized Hypercycles and Protocells.html
- HTML09_Unified Genomes.html
- HTML10_Continuity from Polynucleotides to the Integrated Cell.html
- MDHYC-1979-Lesson-9_lecture_notes.md